Suppose that I'm working on a medical treatment for a project with no known cure

Suppose that I'm working on a medical treatment for a project with no known cure

Suppose that I'm working on a medical treatment for a project with no known cure or even treatment. My subjects report that they feel much better after receiving the treatment, but subsequent study shows that the treatment is, in fact, ineffective and all that I'm seeing is the placebo effect. Can I ethically tell them the truth and thereby make them feel worse subjectively? Would that violate the "do no harm" principle of medical ethics?

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